Ideal candidates should possess proven scientific skills and accomplishments in an industrial setting. Ideally, the candidate should have worked with RELION (and/or cryoSPARC) extensively and can provide expert-level advice on supporting, troubleshooting, and enhancing the applications.

Experience includes any of the following:

Structure-Based Drug Design (SBDD), support of hit expansion, hit-to-lead, lead optimization, and molecular docking. Knowledge of drug discovery packages, e.g. Schrodinger, OpenEye, MOE or Cresset would be a great asset.

Key responsibilities include guiding building applications and workflows for:

- Protein Structure determination and atomic model prediction

- Structure- and ligand-based Drug Design

- Performing protein: small molecule and protein: protein docking

- Virtual screening of molecular databases

- Support of hit-to-lead campaigns and integration of the biological data

- Lead optimization for further ligand refinement

Requirements:

- Ph.D. in relevant discipline with a minimum of 2 years of experience in the industry. Postdoc experience may be substituted for industry experience.

- Expertise in molecular modeling techniques, and protein docking methods including induced fit docking

- Good knowledge of molecular or structural biology and biophysics

- Knowledgeable about the state-of-the-art SBDD challenges and opportunities.

- Development/understanding of multi-step workflows needed in SBDD

- Good programming skills

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